Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
2 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 355.00 | |
50 mg | In stock | $ 597.00 | |
100 mg | In stock | $ 852.00 | |
500 mg | In stock | $ 1,730.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death. |
Molecular Weight | 345.44 |
Formula | C15H15N5OS2 |
CAS No. | 1226443-41-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62 mg/mL (179.48 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
HQ461 1226443-41-9 Cell Cycle/Checkpoint PROTAC CDK Molecular Glues cyclin K degrader Cyclin dependent kinase molecular glue HQ-461 HQ 461 CDK12 substrate phosphorylation inhibit Inhibitor DNA damage inhibitor