Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 169.00 | |
25 mg | In stock | $ 353.00 | |
50 mg | In stock | $ 538.00 | |
100 mg | In stock | $ 777.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 118.00 |
Description | HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM. |
Targets&IC50 | RIP3:20.8 nM |
In vitro | HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action.?Moreover, the compound inhibited TNF-induced necroptosis but did not inhibit TNF-induced apoptosis, indicating that this novel inhibitor has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity.?HS-1371 could serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation. |
Molecular Weight | 384.47 |
Formula | C24H24N4O |
CAS No. | 2158197-70-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (43.36 mM)
You can also refer to dose conversion for different animals. More
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HS-1371 2158197-70-5 Apoptosis NF-Κb RIP kinase Inhibitor Receptor-interacting protein kinases HS1371 RIPK inhibit HS 1371 inhibitor