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HS-1371

Catalog No. T6815   CAS 2158197-70-5

HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.

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HS-1371 Chemical Structure
HS-1371, CAS 2158197-70-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 48.00
5 mg In stock $ 97.00
10 mg In stock $ 169.00
25 mg In stock $ 353.00
50 mg In stock $ 538.00
100 mg In stock $ 777.00
1 mL * 10 mM (in DMSO) In stock $ 118.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
Targets&IC50 RIP3:20.8 nM
In vitro HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action.?Moreover, the compound inhibited TNF-induced necroptosis but did not inhibit TNF-induced apoptosis, indicating that this novel inhibitor has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity.?HS-1371 could serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation.
Molecular Weight 384.47
Formula C24H24N4O
CAS No. 2158197-70-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16.67 mg/mL (43.36 mM)

TargetMolReferences and Literature

1. Park HH, Park SY, Mah S et al.HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis[J]. Exp Mol Med. 2018 Sep 20;50(9):125.

Related compound libraries

This product is contained In the following compound libraries:
Kinase Inhibitor Library Anti-Liver Cancer Compound Library Pyroptosis Compound Library NF-κB Signaling Compound Library Cytokine Inhibitor Library NO PAINS Compound Library Inhibitor Library Anti-Breast Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Ovarian Cancer Compound Library

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Keywords

HS-1371 2158197-70-5 Apoptosis NF-Κb RIP kinase Inhibitor Receptor-interacting protein kinases HS1371 RIPK inhibit HS 1371 inhibitor

 

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