store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 263.00 | |
5 mg | In stock | $ 557.00 | |
10 mg | In stock | $ 786.00 | |
25 mg | In stock | $ 1,230.00 | |
50 mg | In stock | Inquiry |
Description | Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells. |
In vitro | Hernandezine inhibits LPS-induced TNF-α expression/production in human macrophage cell lines (THP-1 and U93). Hernandezine inhibits the transport function of ABCB1, and enhances drug-induced apoptosis in cancer cells. Hernandezine significantly resensitizes ABCB1-overexpressing cancer cells to multiple chemotherapeutic drugs at nontoxic, nanomolar concentrations[1]. |
Molecular Weight | 652.78 |
Formula | C39H44N2O7 |
CAS No. | 6681-13-6 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Hernandezine 6681-13-6 Apoptosis Chromatin/Epigenetic Immunology/Inflammation Membrane transporter/Ion channel Neuroscience PI3K/Akt/mTOR signaling ROS TNF AMPK P-gp inhibitor inhibit