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Hexamethylene amiloride

Catalog No. T4699 CAS 1428-95-1

Synonyms: HMA-5, 5-HMA, 5-(N,N-Hexamethylene)amiloride

HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 µM for various NHE isoforms. HMA also blocks ASIC3 channels by 51% at 20 µM.

Hexamethylene amiloride, CAS 1428-95-1

Pack Size	Availability	Price/USD
5 mg	In stock	50.00
10 mg	In stock	77.00
50 mg	In stock	167.00

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Purity 85.48%

LCMS COA Datasheet MSDS

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Storage & Solubility Information

Description	HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 µM for various NHE isoforms. HMA also blocks ASIC3 channels by 51% at 20 µM.
Targets&IC50

Synonyms	HMA-5 , 5-HMA , 5-(N,N-Hexamethylene)amiloride
Purity	85.48%
Molecular Weight	311.77
Formula	C12H18ClN7O
CAS No.	1428-95-1

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

0.1 N HCl: 20 mg/mL

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Banke T G . The dilated TRPA1 channel pore state is blocked by amiloride and analogues.[J]. Brain Research, 2011, 1381(1381):21-30. 2. Masereel B, et al. An overview of inhibitors of Na(+)/H(+) exchanger.[J]. Eur J Med Chem. 2003 Jun;38(6):547-54. 3. Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3)[J]. Bioorg Med Chem Lett. 2009 May 1;19(9):2514-8. 4. Chessell I P, Michel A D, Humphrey P P. Effects of antagonists at the human recombinant P2X7 receptor.[J]. Br J Pharmacol. 1998 Jul;124(6):1314-20.

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This product is contained In the following compound libraries：

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