Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spliceosome assembly, specifically preventing B complex formation. Hinokiflavone is a SUMO protease inhibitor, inhibiting sentrin-specific protease 1 (SENP1) activity.Hinokiflavone has significant cytotoxicity, it has inhibition of MMP-9.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 113.00 | |
10 mg | In stock | $ 168.00 | |
25 mg | In stock | $ 283.00 | |
50 mg | In stock | Inquiry |
Description | Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spliceosome assembly, specifically preventing B complex formation. Hinokiflavone is a SUMO protease inhibitor, inhibiting sentrin-specific protease 1 (SENP1) activity.Hinokiflavone has significant cytotoxicity, it has inhibition of MMP-9. |
In vitro | Hinokiflavone exhibited a time- and dose-dependent manner apoptosis induction by upregulating expression of Bax and downregulating Bcl-2 in breast cancer cells.?Furthermore, hinokiflavone significantly inhibited the migration and invasion of breast cancer cells by impairing the process of epithelial-to-mesenchymal transition.?The tumour growth was distinctly inhibited by treatment of hinokiflavone in a xenograft tumour mouse model of MDA-MB-231 cells.?Immunohistochemical analysis of tumour sections showed that MMP-2+ cells and Ki-67+ cells were remarkably decreased in tumour tissues of mice after treatment of hinokiflavone, indicating that hinokiflavone inhibits not only proliferation but also metastasis of breast cancer cells.Hinokiflavone can be a potential drug to breast cancer[2]. |
Source |
Molecular Weight | 538.46 |
Formula | C30H18O10 |
CAS No. | 19202-36-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
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Hinokiflavone 19202-36-9 Apoptosis Proteases/Proteasome Ubiquitination MMP BCL E1/E2/E3 Enzyme E2 conjugating enzyme E3 ligating enzyme E1 activating enzyme Ubiquitin ligase Ubiquitin conjugating enzyme Inhibitor Ubiquitin activating enzyme inhibit inhibitor