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Honokiol

Catalog No. T3001   CAS 35354-74-6
Synonyms: NSC 293100

Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.

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Honokiol Chemical Structure
Honokiol, CAS 35354-74-6
Pack Size Availability Price/USD Quantity
50 mg In stock $ 50.00
100 mg In stock $ 63.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.87%
Purity: 99.65%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
Cell Research Honokiol is dissolved in DMSO. In cytotoxicity assays, 10,000 cells/well are added to 96 wells plates and incubated overnight, thereafter cells are treated with different concentrations of Honokiol dissolved in dimethylsulphoxide (DMSO). Since Honokiol is not soluble in aqueous solvents, for in vitro studies Honokiol is dissolved in DMSO. To study the possible effect of DMSO on cells, solvent (DMSO) control is used at highest concentration of <0.1%. After 72 h treatment, cells are fixed and cell viability is measured by crystal violet staining (0.05%).
Source
Synonyms NSC 293100
Molecular Weight 266.33
Formula C18H18O2
CAS No. 35354-74-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 26.6 mg/mL (100 mM)

DMSO: 26.6 mg/mL (100 mM)

TargetMolReferences and Literature

1. Bai X, et al. J Biol Chem, 2003, 278(37), 35501-35507. 2. Ishitsuka K, et al. Blood, 2005, 106(5), 1794-800. 3. Battle TE, et al. Blood, 2005, 106(2), 690-697. 4. Wang T, et al. World J Gastroenterol, 2004, 10(15), 2205-2208. 5. Ahn KS, et al. Mol Cancer Res, 2006, 4(9), 621-633. 6. Godugu C, et al. Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC). Colloids Surf B Biointerfaces. 2017 Jan 23;153:208-219 7. Lee TY, et al. Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies. Sci Rep. 2017 Jan 5;7:40002

TargetMolCitations

1. Zhang Y, Liu Y, Hou M, et al.Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3‐COX4I2 Axis Attenuates Osteoarthritis Progression.Advanced Science.2023: 2206144.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Autophagy Compound Library Anti-infective Natural Product Library Natural Product Library Oxidation-Reduction Compound Library Bioactive Compound Library Apoptosis Compound Library Anti-Ovarian Cancer Compound Library

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Keywords

Honokiol 35354-74-6 Autophagy Cytoskeletal Signaling MAPK Microbiology/Virology PI3K/Akt/mTOR signaling Proteases/Proteasome MEK Akt ERK HCV Protease Inhibitor inhibit HCV NSC 293100 Hepatitis C virus NSC293100 Protein kinase B PKB NSC-293100 Extracellular signal regulated kinases inhibitor

 

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