Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 147.00 | |
5 mg | In stock | $ 447.00 | |
10 mg | In stock | $ 659.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,390.00 | |
100 mg | In stock | $ 1,880.00 | |
500 mg | In stock | $ 3,780.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 417.00 |
Description | ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM). |
Targets&IC50 | Leishmania tropica:2.1 μM |
In vitro | ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters, at increased pacing frequencies. The SK channel inhibitor ICA shows antiarrhythmic effects. ICA at 1 to 10 μM displays conduction velocity[2]. |
Synonyms | N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine |
Molecular Weight | 254.31 |
Formula | C13H10N4S |
CAS No. | 3374-88-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 49.5 mg/mL (194.64 mM)
You can also refer to dose conversion for different animals. More
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ICA 3374-88-7 Membrane transporter/Ion channel Microbiology/Virology Potassium Channel Parasite N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine inhibit Inhibitor inhibitor