Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 413.00 | |
10 mg | In stock | $ 618.00 | |
25 mg | In stock | $ 985.00 | |
50 mg | In stock | $ 1,330.00 | |
100 mg | In stock | $ 1,790.00 | |
500 mg | In stock | $ 3,590.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 455.00 |
Description | ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor. |
Targets&IC50 | Eselectin:7 nM , ICAM1:5 nM |
In vivo | In both a rat model of rheumatoid arthritis and a mouse model of asthma, ICAM-1-IN-1 demonstrates significant therapeutic effects. Notably, after nine days of treatment with ICAM-1-IN-1, there is a reduction in the swelling of inflamed ankles in the rat arthritis model; however, it does not exhibit efficacy during the acute phase of the condition. A 21-day regimen of ICAM-1-IN-1 at a dosage of 25 mg/kg markedly decreases ankle inflammation in arthritic rats. Additionally, this treatment leads to a notable decrease in eosinophil counts and levels of serum-soluble ICAM-1 (sICAM-1). |
Molecular Weight | 363.23 |
Formula | C15H11BrN2O2S |
CAS No. | 251994-14-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 135 mg/mL (371.67 mM)
You can also refer to dose conversion for different animals. More
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ICAM-1-IN-1 251994-14-6 Cytoskeletal Signaling Integrin ICAM 1 IN 1 inhibit ICAM1IN1 Inhibitor inhibitor