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ICG-001

Catalog No. T6113 CAS 780757-88-2

ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.

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ICG-001, CAS 780757-88-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 108.00
25 mg	In stock	$ 218.00
50 mg	In stock	$ 379.00
100 mg	In stock	$ 588.00
500 mg	In stock	$ 1,260.00
1 mL * 10 mM (in DMSO)	In stock	$ 78.00

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Purity: 100%

Purity: 99.55%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
Targets&IC50	CBP:3 μM

Molecular Weight	548.63
Formula	C33H32N4O4
CAS No.	780757-88-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

2% DMSO+40% PEG300+5% Tween 80+53% Saline: 10 mg/mL (Sonification is recommended)

DMSO: 100 mg/mL (182.27 mM)

Ethanol: 9 mg/mL(16.4 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Emami KH, et al, Proc Natl Acad Sci USA, 2004, 101(34), 12682-12687. 2. Teo JL, et al, Proc Natl Acad Sci USA, 2005, 102(34), 12171-12176.

Citations

1. Miao H, Wang Y, Su W, et al.Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway.Acta Pharmacologica Sinica.2023: 1-13. 2. Yu Z, Gao R, Lv C, et al.Notoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling.Acta Pharmacologica Sinica.2024: 1-15.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ICG-001 780757-88-2 Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling Stem Cells Epigenetic Reader Domain Wnt/beta-catenin inhibit Inhibitor Beta catenin β-catenin ICG 001 ICG001 847591-62-2 inhibitor

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