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ICI 153110

Catalog No. T11609 CAS 87164-90-7

ICI 153110 is an orally active phosphodiesterase inhibitor with both inotropic and vasodilating properties. It is designed for the treatment of congestive cardiac failure.

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ICI 153110, CAS 87164-90-7

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

ICI 153110 is an orally active phosphodiesterase inhibitor with both inotropic and vasodilating properties. It is designed for the treatment of congestive cardiac failure.

In vivo

Administration of ICI 153110 resulted in the death of fourteen animals in both high-dose main test and reversibility groups, due to direct or indirect effects. In a female rat receiving 10 mg/kg/day of ICI 153110, a mild focal arteritis was observed, characterized by mixed cell infiltration and early fibrous tissue formation in the artery's outer layer. Premature deaths of two rats were attributed to complications from intratracheal intubation with a dosing solution at 250 mg/kg/day. Additionally, minimal focal arteritis with medial necrosis and inflammation in both the middle and outer layers of the arteries was detected in two other animals administered doses of 5 and 250 mg/kg/day. ICI 153110, an orally active compound with vasodilating and inotropic effects, is aimed at treating congestive cardiac failure.

Molecular Weight	201.22
Formula	C11H11N3O
CAS No.	87164-90-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Westwood FR, et al. Pathologic changes in blood vessels following administration of an inotropic vasodilator (ICI 153,110) to the rat. Fundam Appl Toxicol. 1990 May;14(4):797-809.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ICI 153110 87164-90-7 Others ICI153110 ICI-153110 inhibitor inhibit

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