Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 33.00 | |
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 347.00 | |
100 mg | In stock | $ 537.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 59.00 |
Description | IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.) |
Targets&IC50 | PI3Kγ:2.62 μM |
In vitro | IITZ-01 enhances autophagosomes formation as indicated by increased expression of LC3-II levels time- and dose-dependently in triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453).?IITZ-01 also demonstrates potent autophagy inhibitory activity in other breast, lung, and colon cancer cells. |
Molecular Weight | 482.51 |
Formula | C26H23FN8O |
CAS No. | 1807988-47-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 150 mg/mL (310.87 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IITZ-01 1807988-47-1 Apoptosis Autophagy PI3K/Akt/mTOR signaling PI3K IITZ01 Phosphoinositide 3-kinase IITZ 01 inhibit Inhibitor inhibitor