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ILK-IN-2

Catalog No. T5488 CAS 1333146-24-9

Synonyms: OSU-T315

ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ILK-IN-2, CAS 1333146-24-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 66.00
2 mg	In stock	$ 97.00
5 mg	In stock	$ 165.00
10 mg	In stock	$ 216.00
25 mg	In stock	$ 275.00
50 mg	In stock	$ 339.00
100 mg	In stock	$ 493.00
1 mL * 10 mM (in DMSO)	In stock	$ 232.00

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Purity: 99.31%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.
In vitro	OSU-T315 exhibited high in vitro potency against a panel of prostate and breast cancer cell lines (IC(50), 1-2.5 μM), while normal epithelial cells were unaffected. OSU-T315 facilitated the dephosphorylation of Akt at Ser-473 and other ILK targets, including glycogen synthase kinase-3β and myosin light chain. Moreover, OSU-T315 suppressed the expression of the transcription/translation factor YB-1 and its targets HER2 and EGFR in PC-3 cells, which could be rescued by the stable expression of constitutively active ILK [1]. The cytotoxicity of OSU-T315 in normal B or T cells was significantly lower (LC50 > 10 μM). OSU-T315 had the effect of dose-dependent cytotoxicity toward 2 CLL-derived cell lines, Mec-1 and OSU-CLL (LC50 of 2-3 μM in both) after 24-hour treatment [2].
In vivo	Athymic nude mice bearing established subcutaneous PC-3 tumors were treated with oral OSU-T315 once daily at 25 and 50 mg/kg or vehicle control. The daily administration of OSU-T315 at both doses was well tolerated. Treatment with oral OSU-T315 in either dose resulted in significant suppression of tumor growth relative to the vehicle control after 35 days of treatment (48% and 62% suppression for 25 and 50 mg/kg, respectively) [1].

Synonyms	OSU-T315
Molecular Weight	533.59
Formula	C30H30F3N5O
CAS No.	1333146-24-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (16.87 mM)

References and Literature

1. Lee SL, et al. Identification and characterization of a novel integrin-linked kinase inhibitor. J Med Chem. 2011 Sep 22;54(18):6364-74. 2. Liu TM, et al. OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells. Blood. 2015 Jan 8;125(2):284-95.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Orally Active Compound Library Cytoskeletal Signaling Pathway Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max Anti-COVID-19 Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ILK-IN-2 1333146-24-9 Cytoskeletal Signaling Integrin OSU-T315 inhibit ILK IN 2 ILKIN2 Inhibitor OSU-T-315 OSU-T 315 inhibitor

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