Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 113.00 | |
5 mg | In stock | $ 242.00 | |
10 mg | In stock | $ 343.00 | |
25 mg | In stock | $ 575.00 | |
50 mg | In stock | $ 823.00 | |
100 mg | In stock | $ 1,130.00 | |
500 mg | In stock | $ 2,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 217.00 |
Description | IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics[1]. |
Molecular Weight | 267.35 |
Formula | C12H17N3O2S |
CAS No. | 218795-74-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (224.42 mM)
You can also refer to dose conversion for different animals. More
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IMM-01 218795-74-5 GPCR/G Protein GTPase IMM 01 IMM01 inhibitor inhibit