Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 35.00 | |
5 mg | In stock | $ 82.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 537.00 | |
100 mg | In stock | $ 778.00 | |
500 mg | In stock | $ 1,590.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 90.00 |
Description | IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4. |
Targets&IC50 | HIV-1 (X4):14.2 nM (in MT-4 cells), HIV-1 (X4):19 nM (in PBMCs), CXCL12-CXCR4:2.1 nM |
In vitro | AMD11070 shows antagonistic activity as it dose-dependently inhibits the CXCL12-induced intracellular calcium flux This calcium flux is inhibited by IT1t dihydrochloride with an IC50 of 23.1[1]. |
In vivo | IT1t dihydrochloride reduces the formation of early metastases of TNBC in a zebrafish xenograft model. After CXCR4 silencing, tumor cell invasion at metastatic sites was effectively reduced [3]. |
Molecular Weight | 479.57 |
Formula | C21H36Cl2N4S2 |
CAS No. | 1092776-63-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27mg/mL (56.3mM)
You can also refer to dose conversion for different animals. More
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IT1t dihydrochloride 1092776-63-0 Autophagy GPCR/G Protein Immunology/Inflammation CXCR IT1t Dihydrochloride IT1t IT-1t dihydrochloride inhibitor inhibit