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Iadademstat dihydrochloride

Catalog No. T5825 CAS 1431303-72-8

Synonyms: ORY-1001(trans)

Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia.

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Iadademstat dihydrochloride Chemical Structure

Iadademstat dihydrochloride, CAS 1431303-72-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
5 mg	In stock	$ 88.00
10 mg	In stock	$ 143.00
25 mg	In stock	$ 296.00
50 mg	In stock	$ 578.00
100 mg	In stock	$ 836.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 98%

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Description	Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia.
In vitro	ORY-1001 is a highly potent and selective KDM1A inhibitor that induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic stem cell capacity in AML.
In vivo	ORY-1001 exhibits potent synergy with standard-of-care drugs and selective epigenetic inhibitors, reduces growth of an AML xenograft model, and extends survival in a mouse PDX (patient-derived xenograft) model of T cell acute leukemia.?Surrogate pharmacodynamic biomarkers developed based on expression changes in leukemia cell lines were translated to samples from patients treated with ORY-1001.?ORY-1001 is a selective KDM1A inhibitor in clinical trials and is currently being evaluated in patients with leukemia and solid tumors.

Synonyms	ORY-1001(trans)
Molecular Weight	303.27
Formula	C15H24Cl2N2
CAS No.	1431303-72-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.03 mg/mL (10 mM)

References and Literature

1. Maes T , Mascaró, Cristina, Tirapu I , et al. ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia[J]. Cancer Cell, 2018:S1535610818300230.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Inhibitor Library Methylation Compound Library Anti-Cancer Compound Library NO PAINS Compound Library Hematonosis Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

ORY1001 DDP-38003 dihydrochloride CP2 Pulrodemstat benzenesulfonate JQKD82 KDM5-C70 Kgp-IN-1 Ryuvidine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Iadademstat dihydrochloride 1431303-72-8 Chromatin/Epigenetic Histone Demethylase RO 7051790 RG 6016 RO7051790 inhibit RG6016 Inhibitor ORY1001 RO-7051790 ORY 1001 Iadademstat Dihydrochloride ORY-1001 Iadademstat RG-6016 ORY-1001(trans) inhibitor

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