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Ibiglustat (L-Malic acid)

Catalog No. T11599   CAS 1629063-78-0
Synonyms: Ibiglustat L-Malic acid, GZ402671 (L-Malic acid), Venglustat (L-Malic acid), SAR402671 (L-Malic acid)

Ibiglustat (L-Malic acid) (Ibiglustat L-Malic acid) is a selective, brain-penetrant, and allosteric inhibitor of glucosylceramide synthase. Ibiglustat (L-Malic acid) can be used in studies about PD Parkinson’s disease, SRT in Fabry’s and Gaucher’s.

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Ibiglustat (L-Malic acid) Chemical Structure
Ibiglustat (L-Malic acid), CAS 1629063-78-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 55.00
2 mg In stock $ 80.00
5 mg In stock $ 155.00
10 mg In stock $ 229.00
25 mg In stock $ 387.00
50 mg In stock $ 575.00
100 mg In stock $ 823.00
1 mL * 10 mM (in DMSO) In stock $ 179.00
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Purity: 99.79%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ibiglustat (L-Malic acid) (Ibiglustat L-Malic acid) is a selective, brain-penetrant, and allosteric inhibitor of glucosylceramide synthase. Ibiglustat (L-Malic acid) can be used in studies about PD Parkinson’s disease, SRT in Fabry’s and Gaucher’s.
In vitro Ibiglustat (L-Malic acid) (1 μM) treated Fabry disease cells are close to the physiological level in untreated WT cells in GL-3 levels. Ibiglustat (L-Malic acid) prevents additional GL-3 accumulation and ameliorates the abundant GL-3 levels in FD cardiomyocytes[4].
Synonyms Ibiglustat L-Malic acid, GZ402671 (L-Malic acid), Venglustat (L-Malic acid), SAR402671 (L-Malic acid)
Molecular Weight 523.57
Formula C24H30FN3O7S
CAS No. 1629063-78-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (171.9 mM)

TargetMolReferences and Literature

1. Glucosylceramide Synthase Inhibitors. WO 2015089067 A1. 2. Iva Stojkovska, et al. Molecular mechanisms of α-synuclein and GBA1 in Parkinson’s disease. Cell Tissue Res. 2017. 3. Christoph Arenz, et al. Recent advances and novel treatments for sphingolipidoses. Future Med. Chem. (2017) 9(14), 1687–1700. 4. Itier JM, et al. Effective clearance of GL-3 in a human iPSC-derived cardiomyocyte model of Fabry disease. J Inherit Metab Dis. 2014 Nov;37(6):1013-22.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Clinical Compound Library Bioactive Compounds Library Max Bioactive Compound Library Drug Repurposing Compound Library

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Keywords

Ibiglustat (L-Malic acid) 1629063-78-0 Metabolism Transferase SAR402671 SAR-402671 GZ 402671 Ibiglustat Ibiglustat L-Malic acid GZ402671 (L-Malic acid) SAR 402671 Venglustat Venglustat (L-Malic acid) SAR402671 (L-Malic acid) GZ-402671 L-Malic acid GZ402671 inhibitor inhibit

 

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