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Icotinib Hydrochloride

Catalog No. T2307 CAS 1204313-51-8

Synonyms: BPI-2009H

Icotinib Hydrochloride (BPI-2009H) is the hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of EGFR, with potential antineoplastic activity. Icotinib selectively inhibits the wild-type and several mutated forms of EGFR tyrosine kinase. This may lead to an inhibition of EGFR-mediated signal transduction and may inhibit cancer cell proliferation. EGFR, a receptor tyrosine kinase, has been upregulated in a variety of cancer cell types.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Icotinib Hydrochloride Chemical Structure

Icotinib Hydrochloride, CAS 1204313-51-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 55.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 143.00
50 mg	In stock	$ 239.00
100 mg	In stock	$ 355.00
200 mg	In stock	$ 527.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 99.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

EGFR:5 nM

Synonyms	BPI-2009H
Molecular Weight	427.88
Formula	C22H22ClN3O4
CAS No.	1204313-51-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12 mg/mL (28.04 mM)

References and Literature

1. Tan F, et al. Lung Y. 2012 May;76(2):177-82.

Related compound libraries

This product is contained In the following compound libraries：

FDA-Approved Kinase Inhibitor Library Inhibitor Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Pancreatic Cancer Compound Library

Related Products

Related compounds with same targets

AEE788 H-9 dihydrochloride MTX-211 EGFR-IN-16 lavendustin C EGFR-IN-82 Astragaloside VI EGFR-IN-85

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Icotinib Hydrochloride 1204313-51-8 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR Epidermal growth factor receptor HER1 Inhibitor BPI-2009H ErbB-1 Icotinib inhibit inhibitor

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