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Ifenprodil

Catalog No. T1186L CAS 23210-56-2

Synonyms: RC 61-91, RC-61-91, RC61-91, RC 6191

Ifenprodil (RC61-91) is an inhibitor of the NMDA receptor, specifically of GluN1 (glycine-binding NMDA receptor subunit 1) and GluN2B (glutamate-binding NMDA receptor subunit 2) subunits. Additionally, Ifenprodil inhibits GIRK channels and interacts with alpha1 adrenergic, serotonin, and sigma receptors.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ifenprodil, CAS 23210-56-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 186.00
2 mg	In stock	$ 257.00
5 mg	In stock	$ 379.00
10 mg	In stock	$ 568.00
25 mg	In stock	$ 913.00
50 mg	In stock	$ 1,230.00
100 mg	In stock	$ 1,680.00
500 mg	In stock	$ 3,360.00
1 mL * 10 mM (in DMSO)	In stock	$ 395.00

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Purity: 99.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	RC 61-91, RC-61-91, RC61-91, RC 6191
Molecular Weight	325.44
Formula	C21H27NO2
CAS No.	23210-56-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/ml (84.5 mM)

References and Literature

1. Reynolds IJ, Miller RJ (1989). "Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines". Mol. Pharmacol. 36 (5): 758–65. PMID 2555674. 2. Wang X, He X, Li T, Shu Y, Qi S, Luan G. Anti-epileptic effect of ifenprodil on neocortical pyramidal neurons in patients with malformations of cortical development. Exp Ther Med. 2017 Dec;14(6):5757-5766. doi: 10.3892/etm.2017.5311. Epub 2017 Oct 16. PubMed PMID: 29285118; PubMed Central PMCID: PMC5740521. 3. Opere CA, Heruye S, Njie-Mbye YF, Ohia SE, Sharif NA. Regulation of Excitatory Amino Acid Transmission in the Retina: Studies on Neuroprotection. J Ocul Pharmacol Ther. 2017 Dec 21. doi: 10.1089/jop.2017.0085. [Epub ahead of print] PubMed PMID: 29267132. 4. Zhang Z, Liu J, Fan C, Mao L, Xie R, Wang S, Yang M, Yuan H, Yang X, Sun J, Wang J, Kong J, Huang S, Sun B. The GluN1/GluN2B NMDA receptor and metabotropic glutamate receptor 1 negative allosteric modulator has enhanced neuroprotection in a rat subarachnoid hemorrhage model. Exp Neurol. 2017 Dec 16;301(Pt A):13-25. doi: 10.1016/j.expneurol.2017.12.005. [Epub ahead of print] PubMed PMID: 29258835.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Inhibitor Library Anti-Viral Compound Library Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ifenprodil 23210-56-2 GPCR/G Protein Neuroscience NMDAR Adrenergic Receptor RC-6191 RC 61-91 RC-61-91 RC61-91 RC6191 RC 6191 inhibitor inhibit

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