Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 70.00 | |
5 mg | In stock | $ 155.00 | |
10 mg | In stock | $ 239.00 | |
25 mg | In stock | $ 363.00 | |
50 mg | In stock | $ 538.00 | |
100 mg | In stock | $ 768.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 198.00 |
Description | Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr |
In vitro |
Ilexgenin A (IA), a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr.treatment with IA attenuated atherosclerosis in high-fat diet-induced apolipoprotein E deficient mice via a series of effects involving regulation of lipid parameters, decrease of atherosclerosis-related indexes, inhibition of inflammatory cytokines secretion and pathological changes of main organs.?The underlying mechanism of IA was investigated on oxidized low-density lipoprotein (Ox-LDL)-induced THP-1 cells.?Pre-treatment with IA decreased active inflammation cytokines involving interleukin-6 (IL-6), IL-1 and tumor necrosis factor-α (TNF-α) expression in a concentration-dependent manner.IA inhibited the phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), IKKα phosphorylation and NF-κB activity induced by Ox-LDL.?Overall, these findings define IA as a novel drug candidate for anti-atherosclerotic therapy[2]. |
Source |
Molecular Weight | 502.68 |
Formula | C30H46O6 |
CAS No. | 108524-94-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (21.88 mM)
You can also refer to dose conversion for different animals. More
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Ilexgenin A 108524-94-3 Apoptosis Immunology/Inflammation IL Receptor TNF inhibit Inhibitor pentacyclic cancer Ilex inflammation hainanensis triterpenoid inhibitor