Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 289.00 | |
50 mg | In stock | $ 447.00 | |
100 mg | In stock | $ 659.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 123.00 |
Description | Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease. |
Targets&IC50 | JNK3:1 μM (IC50), JNK1:0.8 μM (IC50), JNK2:1.4 μM (IC50) |
In vitro | clear efficacy of I3M + Tq combinations in LC models mediated by suppressing Akt/mTOR/NFκB signalling. |
In vivo | indirubin-3'-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta 25-35 (Aβ25-35), and also suppressed apoptosis by reducing tau phosphorylation at Ser199 and Thr205.?Furthermore, indirubin-3'-monoxime inhibited phosphorylation of glycogen synthase kinase-3β (GSK-3β).?indirubin-3'-monoxime reduced Aβ25-35-induced apoptosis by suppressing tau hyperphosphorylation via a GSK-3β-mediated mechanism.?Indirubin-3'-monoxime is a promising drug candidate for Alzheimer's disease. |
Synonyms | Indirubin-3'-monoxime |
Molecular Weight | 277.28 |
Formula | C16H11N3O2 |
CAS No. | 667463-82-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (198.36 mM)
You can also refer to dose conversion for different animals. More
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Indirubin-3′-oxime 667463-82-3 Cell Cycle/Checkpoint MAPK PI3K/Akt/mTOR signaling Stem Cells GSK-3 JNK CDK antiplatelet IDR3O Glycogen synthase kinase-3 induced phosphorylation indirubin Inhibitor Cyclin dependent kinase Indirubin3′oxime chondrocytes collagen I3O Glycogen synthase kinase 3 MEF2D Indirubin 3′ oxime Indirubin-3'-monoxime inhibit inhibitor