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Integrin-IN-2

Catalog No. T11663 CAS 2378617-67-3

Integrin-IN-2 is an orally bioavailable pan αv integrin inhibitor.Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively.

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Integrin-IN-2, CAS 2378617-67-3

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25 mg	6-8 weeks	$ 1,520.00

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Biological Description

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Description	Integrin-IN-2 is an orally bioavailable pan αv integrin inhibitor.Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively.
Targets&IC50	αvβ5:8.4, αvβ6:7.8(pIC50), αvβ3:8.4, αvβ8:7.4
In vivo	In vivo pharmacokinetic studies conducted on CD rats have demonstrated that the racemic compound Integrin-IN-2 (compound 39) displays a low plasma clearance rate of 8 mL/(min·kg), coupled with a low to moderate distribution volume of 0.5 L/kg. It exhibits a moderate half-life of 1.8 hours and an exceptionally high bioavailability of 98%.

Molecular Weight	458.55
Formula	C27H30N4O3
CAS No.	2378617-67-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Anderson NA, et al. Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis. J Med Chem. 2019 Oct 10;62(19):8796-8808.

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Keywords

Integrin-IN-2 2378617-67-3 Others Integrin IN 2 IntegrinIN2 inhibitor inhibit

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