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Ipriflavone

Catalog No. T0309 CAS 35212-22-7

Synonyms: Osteofix

Ipriflavone (Osteofix) (Osteofix) is a feed additive and a catabolic agent. It is used to inhibit bone resorption.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ipriflavone, CAS 35212-22-7

Pack Size	Availability	Price/USD
500 mg	In stock	$ 42.00
1 g	In stock	$ 50.00
5 g	In stock	$ 68.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.87%

Purity: 99.82%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ipriflavone (Osteofix) (Osteofix) is a feed additive and a catabolic agent. It is used to inhibit bone resorption.
In vitro	Ipriflavone significantly inhibits the growth of MDA-231 xenograft tumors; treated mice exhibited a reduction in tumor volume by 25% and 45% and a decrease in weight by 47% and 63% compared to the control group, respectively, along with extended survival times of the tumor-bearing mice. Additionally, oral administration of 12 mg of Ipriflavone markedly suppressed the development of osteolytic metastases in bone metastatic cancer, impeded the progression of osteolytic lesions, and reduced the number of osteoclasts adjacent to cancer cells.
In vivo	Ipriflavone modulates the differentiation and biosynthesis of human bone marrow stromal osteoprogenitor cells (BMCs) by enhancing the expression of certain key matrix proteins and promoting mineralization. In cultured murine undifferentiated osteoblasts, 10 mM Ipriflavone significantly inhibits bone resorption augmented by glycation end products. At a 50 mM dose, Ipriflavone does not induce apoptosis in MDA-231 cells. Additionally, Ipriflavone exhibits a dose-dependent inhibition of MDA-231 cell proliferation and DNA synthesis and impedes ligand-induced phosphorylation of Tyr845 in the EGFR.
Cell Research	Cells are exposed to various concentrations of Ipriflavone for 24, 48, 72 and 96 hours. Cells are treated with trypan blue to estimate the number of viable cells. For thymidine incorporation analysis, [3H]Thymidine (1 μCi) is added, and cells are harvested onto glass fiber filters 4 hours later. Radioactivity is determined by scintillation counting.(Only for Reference)

Synonyms	Osteofix
Molecular Weight	280.32
Formula	C18H16O3
CAS No.	35212-22-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 2 mg/mL (7.13 mM)

DMSO: 52 mg/mL (185.5 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Cheng SL, et al. Calcif Tissue Int, 1994, 55(5), 356-362. 2. Miyata T, et al. J Am Soc Nephrol, 1997, 8(2), 260-270. 3. Arjmandi BH, et al. Calcif Tissue Int, 2000, 67(3), 225-229. 4. Iwasaki T, et al. Int J Cancer, 2002, 100(4), 381-387. 5. Han, Yuanyuan, et al. Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway. Drug design, development and therapy. 2018 Jan 11;12:137-148.

Citations

1. Han Y, Wang X, Ma D, et al. Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway. Drug Design Development and Therapy. 2018, 12: 137

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Drug-Fragment Library NO PAINS Compound Library Human Metabolite Library Anti-Aging Compound Library Endocrinology-Hormone Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Ipriflavone 35212-22-7 Others advanced glycation end products Osteofix Inhibitor inhibit inhibitor

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