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Angiogenesis HER Irbinitinib

Irbinitinib

Catalog No. T2364   CAS 937263-43-9
Synonyms: ARRY-380, ONT-380, Tucatinib
Purity 99.96% Datasheet MSDS

Irbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).

Irbinitinib, CAS 937263-43-9
Pack Size Availability Price/USD Quantity
2 mg In stock 50.00
5 mg In stock 61.00
10 mg In stock 86.00
25 mg In stock 143.00
50 mg In stock 230.00
100 mg In stock 410.00
500 mg Inquiry 1490.00
1 mL * 10 mM (in DMSO) In stock 94.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Irbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).
Targets&IC50 EGFR :ic50 4000nM,   HER2/ErbB2 :ic50 8nM,   p95 HER2 :ic50 7nM,  
In vitro Irbinitinib selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells.
In vivo In vivo, ARRY-380 significantly inhibits tumor growth in multiple HER2-dependent tumor xenograft models[2]. It shows excellent activity in numerous mouse tumor models including breast (BT-474, MDA-MB-453), ovarian (SKOV-3) and gastric (N87) carcinoma models. In the BT-474 model, ARRY-380 demonstrated significant dose-related tumor growth inhibition (TGI; 50% at 50 mg/kg/d and 96% at 100 mg/kg/d) with numerous partial regressions (>50% reduction from baseline size)[1].
Animal Research
Animal Model: nude mice
Synonyms ARRY-380, ONT-380, Tucatinib
Purity 98.00%
Appearance solid
Molecular Weight 480.52
Formula C26H24N8O2
CAS No. 937263-43-9

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 87 mg/mL (181.1 mM)

Ethanol: 15 mg/mL (31.22 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. P Lee, et al. Cancer Research(Poster Session Abstracts). 2009, 69(24 Suppl):Abstract nr 5104. 2. SL Moulder, et al. AACR-NCI-EORTC. Nov 12-16, 2011, Abstract#A143.

Related Compound Libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Tyrosine kinase inhibitor library Kinase Inhibitor Library Anti-cancer Clinical Compound Library Angiogenesis related Compound Library JAK STAT Compound Library

Related Products

Related compounds with same targets
Afatinib Dimaleate AG-1478 Afatinib Neratinib Neratinib Irbinitinib BMS 599626 Poziotinib

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