-20℃ 3 years powder
-80℃ 2 years in solvent
Irbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | 50.00 | |
5 mg | In stock | 61.00 | |
10 mg | In stock | 86.00 | |
25 mg | In stock | 143.00 | |
50 mg | In stock | 230.00 | |
100 mg | In stock | 410.00 | |
500 mg | In stock | 1490.00 | |
1 mL * 10 mM (in DMSO) | In stock | 94.00 |
Description | Irbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM). |
Targets&IC50 | EGFR :ic50 4000nM, HER2/ErbB2 :ic50 8nM, p95 HER2 :ic50 7nM, |
In vitro | Irbinitinib selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. |
In vivo | In vivo, ARRY-380 significantly inhibits tumor growth in multiple HER2-dependent tumor xenograft models[2]. It shows excellent activity in numerous mouse tumor models including breast (BT-474, MDA-MB-453), ovarian (SKOV-3) and gastric (N87) carcinoma models. In the BT-474 model, ARRY-380 demonstrated significant dose-related tumor growth inhibition (TGI; 50% at 50 mg/kg/d and 96% at 100 mg/kg/d) with numerous partial regressions (>50% reduction from baseline size)[1]. |
Animal Research |
Animal Model: nude mice
|
Synonyms | ARRY-380 , ONT-380 , Tucatinib |
Purity | 99.96% |
Molecular Weight | 480.52 |
Formula | C26H24N8O2 |
CAS No. | 937263-43-9 |
-20℃ 3 years powder
-80℃ 2 years in solvent
DMSO: 87 mg/mL (181.1 mM)
Ethanol: 15 mg/mL (31.22 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
Safe and effective drug dosing is necessary, regardless of its purpose of administration. Learn More
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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.