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Irbinitinib

Catalog No. T2364 CAS 937263-43-9

Synonyms: ARRY-380, ONT-380, Tucatinib

Purity 99.96% Datasheet MSDS

Irbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).

Irbinitinib, CAS 937263-43-9

Pack Size	Availability	Price/USD
2 mg	In stock	50.00
5 mg	In stock	61.00
10 mg	In stock	86.00
25 mg	In stock	143.00
50 mg	In stock	230.00
100 mg	In stock	410.00
500 mg	In stock	1490.00
1 mL * 10 mM (in DMSO)	In stock	94.00

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Purity 99.96%

HNMR HPLC COA Datasheet MSDS

Purity 98.00%

HNMR COA Datasheet MSDS

Purity 99.96%

HNMR HPLC COA Datasheet MSDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Irbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).
Targets&IC50	EGFR :ic50 4000nM, HER2/ErbB2 :ic50 8nM, p95 HER2 :ic50 7nM,
In vitro	Irbinitinib selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells.
In vivo	In vivo, ARRY-380 significantly inhibits tumor growth in multiple HER2-dependent tumor xenograft models[2]. It shows excellent activity in numerous mouse tumor models including breast (BT-474, MDA-MB-453), ovarian (SKOV-3) and gastric (N87) carcinoma models. In the BT-474 model, ARRY-380 demonstrated significant dose-related tumor growth inhibition (TGI; 50% at 50 mg/kg/d and 96% at 100 mg/kg/d) with numerous partial regressions (>50% reduction from baseline size)[1].
Animal Research	Animal Model: nude mice

Synonyms	ARRY-380 , ONT-380 , Tucatinib
Purity	99.96%
Molecular Weight	480.52
Formula	C26H24N8O2
CAS No.	937263-43-9

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 87 mg/mL (181.1 mM)

Ethanol: 15 mg/mL (31.22 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. P Lee, et al. Cancer Research(Poster Session Abstracts). 2009, 69(24 Suppl):Abstract nr 5104. 2. SL Moulder, et al. AACR-NCI-EORTC. Nov 12-16, 2011, Abstract#A143.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Tyrosine kinase inhibitor library Kinase Inhibitor Library Anti-cancer Clinical Compound Library Angiogenesis related Compound Library JAK STAT Compound Library

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Related compounds with same targets

EGFR-IN-7 Cetuximab (anti-EGFR) Panitumumab CP724714 Nimotuzumab Epidermal Growth Factor Matuzumab Lapatinib Ditosylate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

1. Please make sure the liquid is clear before adding the next solvent.
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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.