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Isoguvacine hydrochloride

Catalog No. T11684   CAS 68547-97-7
Synonyms: 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride

Isoguvacine hydrochloride (1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride) is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.

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Isoguvacine hydrochloride Chemical Structure
Isoguvacine hydrochloride, CAS 68547-97-7
Pack Size Availability Price/USD Quantity
10 mg In stock $ 30.00
25 mg In stock $ 57.00
50 mg In stock $ 96.00
100 mg In stock $ 147.00
500 mg In stock $ 369.00
1 mL * 10 mM (in DMSO) In stock $ 29.00
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Purity: 99.41%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Isoguvacine hydrochloride (1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride) is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.
In vitro Treatment of 50 μM Isoguvacine to block epileptiform events in 2 of 6 organotypic hippocampal slice cultures, Isoguvacine dose-dependently inhibits hypomagnesium-induced epileptiform events[2]. Isoguvacine binds to mouse forebrain synaptic membrane preparations and can specifically bind to GABA, muscimol and bicuculline, but not picrotoxin or diaminobutyric acid. The highest levels of binding are observed in the cerebellum, cortex and hippocampus[3].
Synonyms 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride
Molecular Weight 163.6
Formula C6H10ClNO2
CAS No. 68547-97-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 90 mg/mL (550.12 mM)

DMSO: 20 mg/mL (122.25 mM), sonification is recommended.

TargetMolReferences and Literature

1. White WF, et al. Isoguvacine binding, uptake, and release: relation to the GABA system. J Neurochem. 1983 Jun;40(6):1701-8. 2. Wahab A, et al. Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Res. 2009 Oct;86(2-3):113-23. 3. Morin AM, et al. The binding of 3H-isoguvacine to mouse brain synapticmembranes. Life Sci. 1980 Apr 14;26(15):1239-45.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Neurotransmitter Receptor Compound Library Bioactive Compound Library Anti-Parkinson's Disease Compound Library Anti-Cancer Compound Library Ion Channel Inhibitor Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Antidepressant Compound Library

Related Products

Related compounds with same targets
Cirsimaritin Nefiracetam Arecaidine hydrobromide Muscimol HBr Phenibut (hydrochloride) CGP 36742 Guvacine hydrobromide Methyl eugenol

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Keywords

Isoguvacine hydrochloride 68547-97-7 Membrane transporter/Ion channel Neuroscience GABA Receptor γ-Aminobutyric acid Receptor Isoguvacine 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride Gamma-aminobutyric acid Receptor Isoguvacine Hydrochloride inhibit Inhibitor inhibitor

 

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