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ISX-9

Catalog No. T2003 CAS 832115-62-5

Synonyms: Isoxazole 9, Isoxazole 9 (ISX-9)

ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer.

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ISX-9, CAS 832115-62-5

Pack Size	Availability	Price/USD
2 mg	In stock	$ 41.00
5 mg	In stock	$ 66.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 157.00
50 mg	In stock	$ 222.00
100 mg	In stock	$ 397.00
500 mg	In stock	$ 936.00
1 mL * 10 mM (in DMSO)	In stock	$ 72.00

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Purity: 99.47%

Purity: 98.26%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer.
In vitro	In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs. [1]
In vivo	In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory. [2]
Cell Research	Cells are treated with different concentrations of Isx-9 (0, 6.25, 12.5, 25, or 50 μM), and 2 days later, cell numbers are counted in a blinded manner to evaluate the effects of Isx-9 on the proliferation/survival of four types of progenitor/precursor cells.(Only for Reference)

Synonyms	Isoxazole 9, Isoxazole 9 (ISX-9)
Molecular Weight	234.27
Formula	C11H10N2O2S
CAS No.	832115-62-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 11 mg/mL (47 mM)

DMSO: 43 mg/mL (183.5 mM)

References and Literature

1. Koh SH, et al. PLoS One. 2015, 10(9), e0138724. 2. Petrik D, et al. FASEB J. 2012, 26(8), 3148-3162.

Citations

1. Sayed S, Shekh M, Song J, et al.ISX9 loaded thermoresponsive nanoparticles for hair follicle regrowth.Materials Today Bio.2023: 100849.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Fibrosis Compound Library Target-Focused Phenotypic Screening Library Wnt/Hedgehog/Notch Compound Library Ion Channel Inhibitor Library Bioactive Compounds Library Max Anti-Cardiovascular Disease Compound Library Cancer Cell Differentiation Compound Library Neural Regeneration Compound Library Neuronal Signaling Compound Library Anti-Ovarian Cancer Compound Library

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Keywords

ISX-9 832115-62-5 Cytoskeletal Signaling Membrane transporter/Ion channel Metabolism Stem Cells Calcium Channel Wnt/beta-catenin Mef2 ISX9 Isoxazole-9 Ca2+ Isoxazole9 Ca channels inhibit Isoxazole 9 neuroD NMDA Inhibitor Isoxazole 9 (ISX-9) ISX 9 Ca2+ channels inhibitor

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