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Ivaltinostat

Catalog No. T14936   CAS 936221-33-9
Synonyms: CG-200745

CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.

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Ivaltinostat Chemical Structure
Ivaltinostat, CAS 936221-33-9
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,670.00
50 mg 6-8 weeks $ 2,180.00
100 mg 6-8 weeks $ 2,800.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.
In vitro CG200745 induces the accumulation of p53. It promotes p53-dependent transactivation, and it also enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins [1,2]. CG-200745 (0-10 μM; 48 hours) reduces the Calu6 cells proliferation to 40% of untreated cells. CG-200745 (0-10 μM; 1-24 hours) treatment with low concentration significantly increases the acetylation of histone H3 and H4 in Calu6 cells at various sites in a time-dependent manner up to 24 hours after treatment. CG-200745 (3 μM; 1-24 hours) significantly increases Calu6 cells proportion in the G2/M phase (69%) [3].
In vivo CG-200745 (p.o.; 30?mg/kg/day; for 7 days) weaken inflammatory cytokines, adhesion molecules, oxidative stress in UUO kidneys [4].
Synonyms CG-200745
Molecular Weight 427.54
Formula C24H33N3O4
CAS No. 936221-33-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Oh ET, et al. Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells. Invest New Drugs. 2012 Apr;30(2):435-42. 2. Hwang JJ, et al. A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-XL. Invest New Drugs. 2012 Aug;30(4):1434-42. 3. Chun SM, et al. Epigenetic modulation with HDAC inhibitor CG200745 induces anti-proliferation in non-small cell lung cancer cells. PLoS One. 2015 Mar 17;10(3):e0119379. 4. Choi HS, et al. Histone deacetylase inhibitor, CG200745 attenuates renal fibrosis in obstructive kidney disease. Sci Rep. 2018 Aug 1;8(1):11546.

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Keywords

Ivaltinostat 936221-33-9 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC CG 200745 CG-200745 CG200745 inhibitor inhibit

 

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