Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. |
Targets&IC50 | JAK2:0.7 nM, FLT3:4 nM, JAK1:26 nM, JAK3:39 nM |
In vitro | JAK2/FLT3-IN-1 (0.005-0.1 μM; for 2 hours) has a dose-dependent effect on the induction of apoptosis in the MV4-11 cells. JAK2/FLT3-IN-1 (0.008-1 μM; for 2 hours) down-regulates p-FLT3 in a dose-dependent manner from 0.008 to 1 μM. JAK2/FLT3-IN-1 (0.005-0.1 μM; for 2 hours) strongly induces cell cycle arrest with a G1/G0 percentage of 85% at 100 nM in the MV4-11 cells. |
In vivo | JAK2/FLT3-IN-1 exhibits significant antitumor effects and the tumor growth inhibitory rates (TGI) were respective 58% and 93% in the MV4-11-bearing mice model. |
Molecular Weight | 467.58 |
Formula | C25H34FN7O |
CAS No. | 2387765-27-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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JAK2/FLT3-IN-1 2387765-27-5 MAPK JNK JAK2/FLT3 IN 1 JAK-2/FLT3-IN-1 JAK2/FLT3IN1 inhibitor inhibit