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JAK3 covalent inhibitor-1

Catalog No. T11709 CAS 2300106-50-5

JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and demonstrating a 246-fold selectivity compared to other JAKs.

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JAK3 covalent inhibitor-1 Chemical Structure

JAK3 covalent inhibitor-1, CAS 2300106-50-5

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 2,720.00
50 mg	10-14 weeks	$ 3,580.00
100 mg	10-14 weeks	$ 4,900.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and demonstrating a 246-fold selectivity compared to other JAKs.
Targets&IC50	JAK3:11 nM

Molecular Weight	448.47
Formula	C22H17FN6O2S
CAS No.	2300106-50-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Casimiro-Garcia A, et al. Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J Med Chem. 2018 Dec 13;61(23):10665-10699.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JAK3 covalent inhibitor-1 2300106-50-5 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK JAK3 covalent inhibitor1 JAK3 covalent inhibitor 1 JAK-3 covalent inhibitor-1 inhibitor inhibit

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