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JNJ-37822681

Catalog No. T27677 CAS 935776-74-2

Synonyms: JNJ37822681, JNJ 37822681

JNJ-37822681 is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor.

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JNJ-37822681, CAS 935776-74-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 148.00
5 mg	In stock	$ 336.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 793.00
50 mg	In stock	$ 1,130.00
100 mg	In stock	$ 1,520.00
500 mg	In stock	$ 2,970.00
1 mL * 10 mM (in DMSO)	In stock	$ 353.00

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Purity: 99.48%

Biological Description

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Description	JNJ-37822681 is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor.
Targets&IC50	D2:0.39 mg/kg(ED50)
In vivo	JNJ-37822681 occupied D2 receptors in rat brain at relatively low doses (ED50 = 0.39 mg/kg) and was effective in animal models of psychosis (e.g., inhibition of apomorphine-induced stereotypy or D-amphetamine/phencyclidine-induced hyperlocomotion)[4].

Synonyms	JNJ37822681, JNJ 37822681
Molecular Weight	372.34
Formula	C17H17F5N4
CAS No.	935776-74-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (147.71 mM)

References and Literature

1. Langlois X, et al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J Pharmacol Exp Ther. 2012 Jul;342(1):91-105. 2. de Waal EJ,et al. Differential responses to JNJ-37822681, a specific and fast dissociating dopamine D2 receptor antagonist, in cynomolgus monkey and Sprague-Dawley rat general toxicology studies: clinical observations, prolactin levels, mammary histopathology findings and toxicokinetics. J Appl Toxicol. 2014 Sep;34(9):974-92. 3. Daly EJ, et al. Metabolic and body mass parameters after treatment with JNJ-37822681, a novel fast-dissociating D2 receptor antagonist, vs olanzapine in patients with schizophrenia. Ann Clin Psychiatry. 2013 Aug;25(3):173-83. 4. Hoeben E, et al. Population pharmacokinetics of JNJ-37822681, a selective fast-dissociating dopamine D₂-receptor antagonist, in healthy subjects and subjects with schizophrenia and dose selection based on simulated D₂-receptor occupancy. Clin Pharmacokinet. 2013 Nov;52(11):1005-15.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library GPCR Compound Library Inhibitor Library Highly Selective Inhibitor Library Bioactive Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max

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Keywords

JNJ-37822681 935776-74-2 GPCR/G Protein Neuroscience Dopamine Receptor JNJ37822681 JNJ 37822681 inhibitor inhibit

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