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JNJ-64619178

Catalog No. T15624 CAS 2086772-26-9

JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.

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JNJ-64619178, CAS 2086772-26-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 79.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 262.00
25 mg	In stock	$ 439.00
50 mg	In stock	$ 648.00
1 mL * 10 mM (in DMSO)	In stock	$ 192.00

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Purity: 99.63%

Purity: 99.59%

Purity: 98.44%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.
Targets&IC50	PRMT5:0.14 nM
In vitro	JNJ-64619178 displays effective and broad inhibition of cellular growth. JNJ-64619178 binds simultaneously to the S-adenosylmethionine (SAM)- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action [1].
In vivo	In several non-small cell lung cancer and small cell lung cancer mouse xenograft models, JNJ-64619178 (p.o.) causes efficient inhibition of dimethylation of SMD1/3 proteins, components of the splicing machinery and direct substrates of the methylosome [1].

Molecular Weight	483.36
Formula	C22H23BrN6O2
CAS No.	2086772-26-9

Storage

store under nitrogen

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (248.26 mM), Sonication is recommended.

References and Literature

1. Tongfei Wu, et al. Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models. 2. Tao H, et al. Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations. Chem Pharm Bull (Tokyo). 2019;67(4):382-388.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Active Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Immunology/Inflammation Compound Library Histone Modification Compound Library Covalent Inhibitor Library Anti-Cancer Compound Library Anti-Lung Cancer Compound Library

Related Products

Related compounds with same targets

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide SW2_110A GSK591 TNG-462 SW2_110A acetate Tazemetostat PRMT4-IN-1 PRMT5-IN-31

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JNJ-64619178 2086772-26-9 Chromatin/Epigenetic Histone Methyltransferase inhibit JNJ64619178 Inhibitor Onametostat JNJ 64619178 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.