Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activation in vitro[2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 33.00 | |
2 mg | In stock | $ 45.00 | |
5 mg | In stock | $ 63.00 | |
10 mg | In stock | $ 102.00 | |
25 mg | In stock | $ 233.00 | |
50 mg | In stock | $ 377.00 | |
100 mg | In stock | $ 551.00 | |
500 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 74.00 |
Description | JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activation in vitro[2]. |
In vitro | JTP-0819958 inhibited the linear polyubiquitination activity by the HOIL-1L/HOIP complex, the HOIL-1L/HOIP/SHARPIN complex, and the HOIP/SHARPIN complex equally, with IC50 values of 4.4, 3.5, and 3.7μM. The inhibitory effects of JTP-0819958 on LUBAC-mediated linear ubiquitin generation and inflammatory cytokine-induced NF-κB activation were confirmed in cellular levels. |
Molecular Weight | 304.27 |
Formula | C17H13NaO4 |
CAS No. | T8951 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL(16.43 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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JTP 0819958 - HOIPIN-1 T8951 NF-Κb IκB/IKK JTP 0819958 HOIPIN1 JTP 0819958 HOIPIN 1 inhibitor inhibit