Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JTT 551 can be used in the research of type 2 diabetes mellitus. JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,970.00 | |
50 mg | 8-10 weeks | $ 2,580.00 | |
100 mg | 8-10 weeks | $ 3,400.00 |
Description | JTT 551 can be used in the research of type 2 diabetes mellitus. JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively. |
Targets&IC50 | PTP1B:0.22 μM , TCPTP:9.3 μM |
In vitro | JTT-551 exhibits low affinity for CD45 protein tyrosine phosphatase (CD45) and leucocyte common antigen-related (LAR) protein tyrosine phosphatase, with dissociation constants (Kis) greater than 30 μM for both. Simultaneously, it enhances insulin-induced deoxyglucose uptake in a dose-dependent manner at concentrations of 10 and 30 μM. Primarily, JTT-551 acts as a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B), demonstrating Kis of 0.22 μM for PTP1B and 9.3 μM for T-cell protein tyrosine phosphatase (TCPTP), thereby indicating its specificity and potential therapeutic utility in modulating insulin sensitivity. |
In vivo | JTT 551 effectively lowers triglyceride (TG) levels at a dosage of 30 mg/kg by Day 7, without impacting insulin and total cholesterol (TC) levels. Additionally, at dosages of 3 mg/kg and 30 mg/kg administered orally (p.o.), this compound demonstrates a dose-dependent reduction in blood glucose levels in db/db mice across multiple time points, specifically on Days 7, 14, and 28. |
Molecular Weight | 605.85 |
Formula | C34H43N3O3S2 |
CAS No. | 776309-04-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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JTT 551 776309-04-7 Others JTT551 JTT-551 inhibitor inhibit