Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 59.00 | |
25 mg | In stock | $ 122.00 | |
50 mg | In stock | $ 198.00 | |
100 mg | In stock | $ 328.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). |
Targets&IC50 | auto-PARsylation of TNKS2:830 nM, auto-PARsylation of TNKS1:1.9 μM |
In vitro | JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC50 value of 470 nM. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells[1]. |
In vivo | JW 55 (100 mg/kg, orally) reduces tumor development in conditional Apc knockout mice. JW55 reduces XWnt8-induced axis duplication inXenopus embryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice[1]. |
Cell Research | JW 55 (JW55) is prepared in DMSO and stored, and then diluted with appropriate medium[1]. A total of 1,000 SW480 or RKO cells are seeded in 96-well plates. The day after, the cell culture medium is exchanged to solutions that contained 0.1% DMSO or 10 μM JW55 for RKO cells and 0.1% DMSO or 10, 5, or 1 μM JW55 for SW480 cells. All samples consist of a minimum of 6 replicates. The plate is incubated in an IncuCyte inside a cell culture incubator. Images are captured every second hour to monitor proliferation[1]. |
Synonyms | JW55 |
Molecular Weight | 434.48 |
Formula | C25H26N2O5 |
CAS No. | 664993-53-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 100 mM
DMSO: 100 mM
You can also refer to dose conversion for different animals. More
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JW 55 664993-53-7 Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Stem Cells Wnt/beta-catenin PARP JW-55 poly ADP ribose polymerase Inhibitor inhibit JW55 inhibitor