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JWG-071

Catalog No. T14547 CAS 2250323-50-1

Synonyms: JWG071, JWG 071

JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD4 selectivity.

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JWG-071, CAS 2250323-50-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 64.00
5 mg	In stock	$ 155.00
10 mg	In stock	$ 195.00
25 mg	In stock	$ 297.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 208.00

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Purity: 98.33%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD4 selectivity.
Targets&IC50	ERK5:88 nM
In vitro	JWG-071 demonstrates IC50 values of 88 nM and 109 nM for inhibiting ERK5 and LRRK2, respectively.[1]

Synonyms	JWG071, JWG 071
Molecular Weight	612.77
Formula	C34H44N8O3
CAS No.	2250323-50-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 61.28 mg/mL (100 mM), Sonification is recommended.

References and Literature

1. Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Histone Modification Compound Library Kinase Inhibitor Library

Related Products

Related compounds with same targets

Bufarenogin NVP 231 Omtriptolide Isomerazin ERK1/2 inhibitor 2 Laxiflorin B Isofraxidin Sulforaphene

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JWG-071 2250323-50-1 Chromatin/Epigenetic MAPK Epigenetic Reader Domain ERK JWG071 JWG 071 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.