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Juglone

Catalog No. T4010   CAS 481-39-0
Synonyms: 5-Hydroxy-1,4-naphthoquinone, Regianin

Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.

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Juglone Chemical Structure
Juglone, CAS 481-39-0
Pack Size Availability Price/USD Quantity
5 mg In stock $ 41.00
10 mg In stock $ 56.00
25 mg In stock $ 96.00
50 mg In stock $ 135.00
100 mg In stock $ 189.00
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Purity: 98.73%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.
Source
Synonyms 5-Hydroxy-1,4-naphthoquinone, Regianin
Molecular Weight 174.15
Formula C10H6O3
CAS No. 481-39-0

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.56 mg/mL (31.9 mM), The compound is unstable in solution and is recommended to be prepared and used immediately.

Ethanol: 15 mg/mL, The compound is unstable in solution and is recommended to be prepared and used immediately.

TargetMolReferences and Literature

1. Hennig L, et al. Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone. Biochemistry. 1998 Apr 28;37(17):5953-60. 2. Chao SH, et al. Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription. Nucleic Acids Res. 2001 Feb 1;29(3):767-73. 3. Reese S, et al. The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model. Fibrogenesis Tissue Repair. 2010 Jan 4;3:1.

Related compound libraries

This product is contained In the following compound libraries:
Tobacco Monomer Library Natural Product Library for HTS Bioactive Compound Library Tibetan medicine Compound Library Anti-Bacterial Compound Library Natural Product Library Anti-Infection Compound Library Selected Plant-Sourced Compound Library Anti-Tumor Natural Product Library RO5 Drug-like Natural Product Library

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Keywords

Juglone 481-39-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology DNA/RNA Synthesis Antibacterial antimicrobial Pigment inhibit Bacterial 5-Hydroxy-1,4-naphthoquinone Inhibitor Yellow black walnut Regianin inhibitor

 

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