Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity of thioredoxin.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 169.00 | |
50 mg | In stock | $ 313.00 | |
100 mg | In stock | $ 493.00 | |
200 mg | In stock | $ 698.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 61.00 |
Description | Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity of thioredoxin. |
Targets&IC50 | Thiordoxine:10μM, Caspase-3:10μM |
In vitro | KEA1-97 (10 μM, 48h) impaired 231MFP cell survival and proliferation and does not affect viability in MCF10A cells. |
In vivo | KEA1–97 treatment (5 mg/kg ip once per day) was initiated 16 days after the initiation of 231MFP tumor xenografts in immune-deficient SCID mice. |
Molecular Weight | 335.16 |
Formula | C15H9Cl2FN4 |
CAS No. | 2138882-71-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL(268.53 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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KEA1-97 2138882-71-8 Apoptosis Others Proteases/Proteasome Caspase KEA1 97 Proliferation Apoptotic inhibit KEA-1-97 DCTalkyne 231MFP Inhibitor Selective KEA197 inhibitor