Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 313.00 | |
50 mg | In stock | $ 497.00 | |
100 mg | In stock | $ 723.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | KLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM). |
In vitro | In Neuro2A cells, KLH45 (25 nM) completely inhibits DDHD2 (>95%)[1]. In fatty acid-supplemented DDHD2-expressing cells, KLH45 (2 μM) increases LD formation and selectively blocks DDHD2 activity[2]. |
In vivo | KLH45 (20 mg/kg) significantly elevates brain triglycerides in DDHD2−/− mice[1]. |
Synonyms | KLH-45, KLH 45 |
Molecular Weight | 458.48 |
Formula | C24H25F3N4O2 |
CAS No. | 1632236-44-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 162.0 mg/mL (353.3 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
KLH45 1632236-44-2 Metabolism Phosphatase KLH-45 KLH 45 inhibitor inhibit