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KPT9274

Catalog No. T4354 CAS 1643913-93-2

Synonyms: KPT-9274, KPT 9274, PAK4-IN-1

KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

KPT9274, CAS 1643913-93-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 75.00
2 mg	In stock	$ 108.00
5 mg	In stock	$ 182.00
10 mg	In stock	$ 291.00
25 mg	In stock	$ 582.00
50 mg	In stock	$ 833.00
100 mg	In stock	$ 1,150.00
1 mL * 10 mM (in DMSO)	In stock	$ 246.00

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Purity: 99.93%

Purity: 99.73%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.
Targets&IC50	NAMPT:~120 nM
In vitro	In several human RCC cell lines, KPT-9274 interferences with PAK4 and NAD biosynthetic pathways leading to reduction of G2/M transit as well as induction of apoptosis and decrease in cell invasion and migration. The inhibition of the PAK4 pathway by KPT-9274 attenuates nuclear β-catenin as well as the Wnt/β-catenin targets cyclin D1 and c-Myc.
In vivo	In mice, KPT-9274 (200 mg/kg) daily is administered either intravenously or orally with the absence of any signs of toxicity.
Cell Research	786-0, ACHN, Caki-1 and U-2 OS cells are treated with KPT-9274 (1 μM and 5 μM) incubating for 12 hours.
Animal Research	786-O (VHL-mut) human RCC xenograft model (nude mice) is treated with KPT-9274 (100 and 200 mg/kg),prepared in 58% Polyvinylpyrrolidone K30 + 21% methyl cellulose + 21% Phospholipon 90 g, by oral gavage.

Synonyms	KPT-9274, KPT 9274, PAK4-IN-1
Molecular Weight	610.62
Formula	C35H29F3N4O3
CAS No.	1643913-93-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (90.07 mM)

References and Literature

1. Abu Aboud O,etal.Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth.Mol Cancer Ther. 2016 Sep;15(9):2119-29.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compound Library NO PAINS Compound Library Anti-Metabolism Disease Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Teglarinad chloride Nampt activator-1 NAMPT degrader-3 OT-82 STF-118804 GNE-618 GNE-617 SBI-797812

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KPT9274 1643913-93-2 Cytoskeletal Signaling Metabolism NAMPT PAK KPT-9274 KPT 9274 PAK4-IN-1 inhibitor inhibit

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