Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KSI-3716 is an inhibitor of c-Myc.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 242.00 | |
5 mg | 5 days | $ 297.00 | |
25 mg | 6-8 weeks | $ 987.00 | |
50 mg | 6-8 weeks | $ 1,360.00 | |
100 mg | 6-8 weeks | $ 1,860.00 |
Description | KSI-3716 is an inhibitor of c-Myc. |
In vitro | KSI-3716 effectively blocks complex formation in a dose dependent manner (IC50=0.84 μM).?c-MYC mediated transcriptional activity is inhibited by KSI-3716 at concentrations as low as 1 μM.?The expression of c-MYC target genes, such as cyclin D2, CDK4 and hTERT, is markedly decreased.?KSI-3716 exerts cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis.KSI-3716 blocks c-MYC/MAX from forming a complex with target gene promoters. |
In vivo | Perfusion of KSI-3716 through the bladder at a dose of 5 mg/kg can significantly inhibit tumor growth with minimal systemic toxicity. |
Molecular Weight | 426.09 |
Formula | C17H11BrCl2N2O2 |
CAS No. | 1151813-61-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (11.73 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
KSI-3716 1151813-61-4 Cell Cycle/Checkpoint c-Myc KSI3716 KSI 3716 inhibitor inhibit