Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KW-8232 free base can reduces the biosynthesis of PGE2, is an anti-osteoporotic agent.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | KW-8232 free base can reduces the biosynthesis of PGE2, is an anti-osteoporotic agent. |
In vitro | KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells.KW-8232 free base is an anti-osteoporotic agent. |
In vivo | KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production.KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. |
Molecular Weight | 609.16 |
Formula | C36H37ClN4O3 |
CAS No. | 170365-25-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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