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Kaempferol 3-neohesperidoside

Catalog No. TN1819   CAS 32602-81-6
Synonyms: Kaempferol 3-O-neohesperidoside

Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside exhibits insulinomimetic effect on the rat soleus muscle.

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Kaempferol 3-neohesperidoside Chemical Structure
Kaempferol 3-neohesperidoside, CAS 32602-81-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 68.00
5 mg In stock $ 160.00
10 mg In stock $ 235.00
25 mg In stock $ 395.00
50 mg In stock $ 587.00
100 mg In stock $ 839.00
1 mL * 10 mM (in DMSO) In stock $ 250.00
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Purity: 98.34%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside exhibits insulinomimetic effect on the rat soleus muscle.
In vitro A stimulatory effect of Kaempferol 3-neohesperidoside ( 1) on glucose uptake (35% and 21%) was observed when the rat soleus muscle was incubated with 1 and 100 nM of this flavonoid glycoside, respectively. The concentration-response curve of insulin showed a stimulatory effect at 3.5 and 7.0 nM (42% and 50%) on glucose uptake when compared with the control group. The effect of Kaempferol 3-neohesperidoside on glucose uptake was completely nullified by pretreatment with LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), and RO318220, an inhibitor of protein kinase C (PKC). However, no significant change occurred on glucose uptake stimulated by Kaempferol 3-neohesperidoside when muscles were pretreated with PD98059, an inhibitor of mitogen-activated protein kinase (MEK), and cycloheximide, an inhibitor of protein synthesis. Kaempferol 3-neohesperidoside and insulin (7 nM) did not show a synergistic effect on glucose uptake. Additionally, 100 mg/kg of Kaempferol 3-neohesperidoside by oral gavage was able to increase glycogen content in the muscle[1]
Source
Synonyms Kaempferol 3-O-neohesperidoside
Molecular Weight 594.52
Formula C27H30O15
CAS No. 32602-81-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (92.51 mM)

TargetMolReferences and Literature

1. Insulinomimetic effect of kaempferol 3-neohesperidoside on the rat soleus muscle.J Nat Prod. 2008 Apr;71(4):532-5.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Liver Cancer Compound Library Polyphenolic Natural Product Library Chinese Pharmacopoeia Natural Product Library NO PAINS Compound Library Anti-Lung Cancer Compound Library Anti-Cancer Metabolism Compound Library Anti-Obesity Compound Library Anti-Diabetic Compound Library Metabolism Compound Library Bioactive Compound Library

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Keywords

Kaempferol 3-neohesperidoside 32602-81-6 MAPK PI3K/Akt/mTOR signaling Stem Cells GSK-3 MEK PI3K Kaempferol 3-O-neohesperidoside inhibit Inhibitor Kaempferol 3neohesperidoside Kaempferol 3 neohesperidoside inhibitor

 

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