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Kisspeptin-10, human (TFA)(374675-21-5,FREE)

Catalog No. TP1345   CAS TP1345

Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression

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Kisspeptin-10, human (TFA)(374675-21-5,FREE) Chemical Structure
Kisspeptin-10, human (TFA)(374675-21-5,FREE), CAS TP1345
Pack Size Availability Price/USD Quantity
1 mg In stock $ 115.00
5 mg In stock $ 385.00
10 mg In stock $ 577.00
25 mg In stock $ 926.00
50 mg In stock $ 1,260.00
100 mg In stock $ 1,680.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression
In vitro KP-10-treatment significantly increased the expression of osteogenic genes, including mRNA and protein levels of BMP2, in C3H10T1/2 cells.?Moreover, KP-10 induced BMP2-luc activity and increased phosphorylation of Smad1/5/9.?In addition, NFATc4 specifically mediated KP-10-induced BMP2 gene expression.?However, KP-10 treatment did not induce expression of the BMP2 and Runx2 genes in GPR54-/- cells.?To examine whether KP-10 induced secretion of BMP2 to the culture medium, we used the conditioned-medium (C.M) of KP-10 treated medium on C3H10T1/2 cells.?Dlx5 and Runx2 expressions were higher in GPR54-/- cells treated with C.M than in those treated with KP-10[1].
Molecular Weight 1416.46
Formula C63H83N17O14.C2HF3O2
CAS No. TP1345

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 4 mg/mL (2.82 mM), sonification is recommended.

TargetMolReferences and Literature

1. Son HE, et al. Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Sci Rep. 2018 Feb 1;8(1):2134.

Related compound libraries

This product is contained In the following compound libraries:
Peptide Compound Library NO PAINS Compound Library Inhibitor Library Endocrinology-Hormone Compound Library

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Keywords

Kisspeptin-10, human (TFA)(374675-21-5,FREE) TP1345 Endocrinology/Hormones GPCR/G Protein GPR Kisspeptin Kisspeptin 10, human (TFA)(374675 21 5,FREE) Kisspeptin10, human (TFA)(374675215,FREE) inhibitor inhibit

 

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