Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 34.00 | |
25 mg | In stock | $ 48.00 | |
50 mg | In stock | $ 74.00 | |
100 mg | In stock | $ 125.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities. |
Targets&IC50 | Ras:149 μM(Ki) |
Kinase Assay | Migration assays: Assays are conducted in wells of a 24-well, 8 μm pore size Transwell plate. A 6.5-mm insert membrane is coated with 0.1 mL COL-I (300 μg/mL in MEGM) and then air dried for 16 hours. The collagen coating is rehydrated for 1 hour in 0.2 mL MEGM. The inner chamber contains MEGM-10% FBS as a chemoattractant. The compounds (10–100 μmol/L) or DMSO (0.1%–1%) are added to both inner and outer chambers. Before plating in the outer chamber, cells (5×104) are coincubated for 20 minutes with the compounds or DMSO in MEGM. Cells are allowed to migrate for 16 to 18 hours. The cells remaining on the top surface of the membrane are removed with a cotton swab. The cells on the bottom surface of the membrane are fixed and stained (0.2% crystal violet). The incorporated dye is extracted with 1% SDS and the A570 is measured. |
Molecular Weight | 419.31 |
Formula | C14H9F4N5O4S |
CAS No. | 454453-49-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (119.24 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Kobe2602 454453-49-7 GPCR/G Protein MAPK Raf Ras H-Ras Inhibitor antiproliferative Kobe-2602 carcinoma Kobe 2602 inhibit inhibitor