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Kumatakenin

Catalog No. TN1839 CAS 3301-49-3

Kumatakenin can suppress >80% of the SOS-inducing activity of Trp-P-1 at <0.06 micromol/mL.

Kumatakenin, CAS 3301-49-3

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10 mg	Inquiry	518.00

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Purity 98.00%

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Description	Kumatakenin can suppress >80% of the SOS-inducing activity of Trp-P-1 at <0.06 micromol/mL.
Targets&IC50	Antifection,
In vitro	The methanol extract was re-extracted with hexane, dichloromethane, butanol, and water. A dichloromethane fraction showed a suppressive effect. Suppressive compounds against furylfuramide in the dichloromethane fraction were isolated by SiO(2) column chromatography and identified as 7,4'-di-O-methyleriodictyol (1), 7, 3',4'-tri-O-methyleriodictyol (2), and 3,7,4'-tri-O-methylkaempferol (3). In addition, three flavonoids, ombuine (4), pachypodol (5), and Kumatakenin (6), were isolated and identified from the dichrolomethane fraction. Compounds 1 and 3 suppressed >50% of the SOS-inducing activity at <0.6 micromol/mL, and the ID(50) values of both compounds were 0.25 micromol/mL. Compound 2 showed a weakly suppressive effect (17%) at a concentration of 0.6 micromol/mL, and compounds 4-6 did not. These compounds were also assayed with 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), which requires liver metabolizing enzymes. Compounds 3,4,5,Kumatakenin (6) suppressed >80% of the SOS-inducing activity of Trp-P-1 at <0.06 micromol/mL, and compounds 1 and 2 suppressed 87 and 63% at a concentration of 0.3 micromol/mL. In addition, these compounds were assayed with activated Trp-P-1, and the suppressed effects of these compounds were further decreased when compared to Trp-P-1.

Molecular Weight	314.3
Formula	C17H14O6
CAS No.	3301-49-3

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Antimutagenic activity of flavonoids from Pogostemon cablin.J Agric Food Chem. 2000 Mar;48(3):642-7.

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