Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in diseases. At the GluN1 glycine binding site, L-689560 is an effective N-methyl-D-aspartate (NMDA) receptor antagonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | 4-5 weeks | $ 668.00 | |
50 mg | 4-5 weeks | $ 2,790.00 |
Description | L-689560 is widely used as a radiolabeled ligand in binding studies and used to study the roles of NMDA receptors in normal neurological processes as well as in diseases. At the GluN1 glycine binding site, L-689560 is an effective N-methyl-D-aspartate (NMDA) receptor antagonist. |
In vitro | L-689560 is an antagonist of 2-carboxytetrahydroquinoline [2]. |
In vivo | L-689560 blocks the glycine-induced increase of Akt phosphorylation in the MCAO model. L-689560 (1?mg/kg, ip) obviously decreases the neuroprotective effect of glycine after glycine receptors, and the channel activity of NMDA receptors (NMDARs) are suppressed [1]. |
Molecular Weight | 380.23 |
Formula | C17H15Cl2N3O3 |
CAS No. | 139051-78-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
L-689560 139051-78-8 Membrane transporter/Ion channel Neuroscience iGluR NMDAR inhibit neurological Ionotropic glutamate receptors NMDA glycine radiolabeled L 689560 Inhibitor ligand 2-carboxytetrahydroquinoline L689560 GluN1 inhibitor