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L-Ascorbic acid 2-phosphate magnesium

Catalog No. T19389 CAS 113170-55-1

Synonyms: 维生素C磷酸酯镁, 维生素 C 磷酸酯镁, 2-Phospho-L-ascorbic acid magnesium

L-Ascorbic acid 2-phosphate magnesium acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production.It is a long-acting vitamin C derivative that can stimulate collagen formation and expression.

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L-Ascorbic acid 2-phosphate magnesium, CAS 113170-55-1

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Purity: 98%

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Description

In vitro

L-Ascorbic acid 2-phosphate (50 μM-250 μM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 μM AsA2-P and 10 nM dexamethasone (Dex), and 250 μM AsA2-P and 5 nM Dex.L-Ascorbic acid 2-phosphate (0.1-1.5 mM;?2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation.?A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect.

Synonyms	维生素C磷酸酯镁, 维生素 C 磷酸酯镁, 2-Phospho-L-ascorbic acid magnesium
Molecular Weight	282.424
Formula	C6H11MgO9P
CAS No.	113170-55-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Shima N, et al. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate.Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8711-7. 2. Kurata S, et al. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative.J Biol Chem. 1991 May 25;266(15):9997-10003. 3. Kyllönen L, et al. Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro.Stem Cell Res Ther. 2013 Feb 15;4(1):17.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Lung Cancer Compound Library Glycometabolism Compound Library Ferroptosis Compound Library Anti-Fibrosis Compound Library Bioactive Compound Library

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Keywords

L-Ascorbic acid 2-phosphate magnesium 113170-55-1 代谢 Phosphatase Phosphorylase Reactive Oxygen Species medium vitamin Endogenous Metabolite osteogenic L Ascorbic acid 2 phosphate magnesium supplement runx2A derivative LAscorbic acid 2phosphate magnesium Inhibitor hASC differentiation inhibit 2-Phospho-L-ascorbic acid magnesium inhibitor

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