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L-Chicoric Acid

Catalog No. T6S2391   CAS 70831-56-0
Synonyms: (-)-Chicoric acid, trans-Caffeoyltartaric acid, Chicoric acid, dicaffeoyltartaric acid

L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may reduce acute alcohol-induced steatosis in mice through interfering with the induction of iNOS and iNOS-dependent signaling cascades in the liver. 3. L-Chicoric acid inhibited cell viability and induced apoptosis in 3T3-L1 preadipocytes which was characterized by chromatin condensation and poly ADP-ribose-polymerase (PARP) cleavage.

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L-Chicoric Acid Chemical Structure
L-Chicoric Acid, CAS 70831-56-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 54.00
5 mg In stock $ 132.00
10 mg In stock $ 197.00
25 mg In stock $ 348.00
50 mg In stock $ 518.00
100 mg In stock $ 742.00
1 mL * 10 mM (in DMSO) In stock $ 156.00
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Purity: 99%
Purity: 98.74%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may reduce acute alcohol-induced steatosis in mice through interfering with the induction of iNOS and iNOS-dependent signaling cascades in the liver. 3. L-Chicoric acid inhibited cell viability and induced apoptosis in 3T3-L1 preadipocytes which was characterized by chromatin condensation and poly ADP-ribose-polymerase (PARP) cleavage.
Targets&IC50 HIV-1 integrase:100 nM (IC50)
Source
Synonyms (-)-Chicoric acid, trans-Caffeoyltartaric acid, Chicoric acid, dicaffeoyltartaric acid
Molecular Weight 474.37
Formula C22H18O12
CAS No. 70831-56-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (105.4 mM)

TargetMolReferences and Literature

1. Xiao H , Wang J , Yuan L , et al. Chicoric Acid Induces Apoptosis in 3T3-L1 Preadipocytes through ROS-Mediated PI3K/Akt and MAPK Signaling Pathways[J]. Journal of Agricultural and Food Chemistry, 2013, 61(7):1509-1520.

TargetMolCitations

1. Jung D H, Lee A, Hwang Y H, et al.Therapeutic effects of Pulsatilla koreana Nakai extract on ovalbumin-induced allergic rhinitis by inhibition of Th2 cell activation and differentiation via the IL-4/STAT6/GATA3 pathway.Biomedicine & Pharmacotherapy.2023, 162: 114730.

Related compound libraries

This product is contained In the following compound libraries:
PPI Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Viral Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Human Metabolite Library Inhibitor Library

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Keywords

L-Chicoric Acid 70831-56-0 Microbiology/Virology Others Proteases/Proteasome HIV Protease replication Inhibitor HIV Integrase (-)-Chicoric acid L Chicoric Acid dicaffeoyltartaric inhibit Noncompetitive trans-Caffeoyltartaric acid Chicoric acid HIV-1 reversible LChicoric Acid antiviral HIV dicaffeoyltartaric acid Human immunodeficiency virus inhibitor

 

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