Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LCH-7749944 (GNF-PF-2356) effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor with an IC50 of 14.93 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 83.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 318.00 | |
25 mg | In stock | $ 533.00 | |
50 mg | In stock | $ 768.00 | |
100 mg | In stock | $ 1,080.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 222.00 |
Description | LCH-7749944 (GNF-PF-2356) effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor with an IC50 of 14.93 μM. |
Targets&IC50 | PAK4:14.93 μM |
In vitro | LCH-7749944 (5-20 μM; 12-48 hours) prominently induces a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase. ?LCH-7749944 (5-30 μM; 24 hours) dramatically decreases levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner.?LCH-7749944 (GNF-PF-2356;?5-50 μM;?24 hours) inhibits the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner.??LCH-7749944 (5-20 μM;?12-48 hours) induces apoptosis of SGC7901 cells. |
Synonyms | GNF-PF-2356 |
Molecular Weight | 350.41 |
Formula | C20H22N4O2 |
CAS No. | 796888-12-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (713.45 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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LCH-7749944 796888-12-5 Apoptosis Cytoskeletal Signaling PAK proliferation cells LCH7749944 Inhibitor c-Src EGFR GNF-PF-2356 inhibit LCH 7749944 gastric GNF-PF 2356 cancer GNF-PF2356 PAK4 human p21 activated kinases cyclin inhibitor