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LDN-212320

Catalog No. T15728   CAS 894002-50-7
Synonyms: LDN-0212320, LDN/OSU-0212320, OSU-0212320

LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by < 6 fold at concentrations < 5 μM after 24 h.

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LDN-212320 Chemical Structure
LDN-212320, CAS 894002-50-7
Pack Size Availability Price/USD Quantity
2 mg In stock $ 39.00
5 mg In stock $ 64.00
10 mg In stock $ 98.00
25 mg In stock $ 198.00
50 mg In stock $ 373.00
100 mg In stock $ 560.00
500 mg In stock $ 1,190.00
1 mL * 10 mM (in DMSO) In stock $ 70.00
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Purity: 98.13%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.
In vitro LDN/OSU-0212320 enhanced EAAT2 protein levels and glutamate uptake function but did not affect EAAT1 or EAAT3 protein levels and it also increased EAAT2 protein levels in a dose-dependent (EC50: 1.83 ± 0.27 μM) and time-dependent manner. LDN/OSU-0212320 treatment markedly prevented neuronal loss and degeneration, as assessed by MAP2 immunostaining [2].
In vivo After LDN/OSU-0212320(a single i.p.; 40-mg/kg) treatment, EAAT2 protein levels and associated glutamate uptake increased by approximately 1.5- to 2-fold at 2 hours and by approximately 2- to 3-fold between 8 and 24 hours after injection. Even 72 hours after injection, an approximately 1.5-fold increase in EAAT2 protein levels could still be detected (data not shown). LDN/OSU-0212320–induced EAAT2 protein levels and glutamate uptake was dose-dependent [2].
Synonyms LDN-0212320, LDN/OSU-0212320, OSU-0212320
Molecular Weight 293.39
Formula C17H15N3S
CAS No. 894002-50-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (153.38 mM), sonification is recommended.

TargetMolReferences and Literature

1. Xing X, et al. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5774-7. 2. Kong Q, et al. Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection. J Clin Invest. 2014 Mar;124(3):1255-67.

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library Bioactive Compound Library Bioactive Compounds Library Max Ion Channel Inhibitor Library Metabolism Compound Library

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Keywords

LDN-212320 894002-50-7 Metabolism transporter Glutamate transporter 1 inhibit EAAT2 LDN/OSU 0212320 LDN/OSU0212320 LDN 0212320 Inhibitor LDN-0212320 LDN 212320 OSU 0212320 OSU0212320 LDN0212320 GLT-1 Excitatory amino acid transporter 2 LDN212320 LDN/OSU-0212320 OSU-0212320 inhibitor

 

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