Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 48.00 | |
10 mg | In stock | $ 74.00 | |
25 mg | In stock | $ 150.00 | |
50 mg | In stock | $ 263.00 | |
100 mg | In stock | $ 397.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 54.00 |
Description | LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM) |
Targets&IC50 | β-catenin/TCF4 (Alpha Screen):1.65 μM , β-catenin/TCF4 (ELISA):1.82 μM |
In vitro | LF3 inhibited Wnt/β-catenin signals in cells with exogenous reporters and in colon cancer cells with endogenously high Wnt activity. LF3 also suppressed features of cancer cells related to Wnt signaling, including high cell motility, cell-cycle progression, and the overexpression of Wnt target genes[1]. |
In vivo | LF3 reduced tumor growth and induced differentiation in a mouse xenograft model of colon cancer.LF3 is a specific inhibitor of canonical Wnt signaling with anticancer activity[1]. |
Animal Research | Unsorted GFPlow and GFPhigh SW480 cells (1 × 10^4) were subcutaneously injected into the back skin of NOD/SCID mice. Tumor growth was monitored over a period of 45 days. For therapy, LF3 was administered i.v. at 50 mg/kg body weight for three rounds over 5 consecutive days, with 2-day breaks[1]. |
Molecular Weight | 416.56 |
Formula | C20H24N4O2S2 |
CAS No. | 664969-54-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32 mg/mL (76.82 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LF3 664969-54-4 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin β-catenin Beta catenin LF 3 LF-3 inhibit Inhibitor inhibitor